Drug interactions
Atenolol-chlorthalidone + Ketorolac
Severity: Moderate
Atenolol-chlorthalidone and Ketorolac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketorolac can blunt the blood pressure-lowering effect of atenolol and chlorthalidone. Combined with a diuretic it raises the risk of acute kidney injury, especially with dehydration, because ketorolac is a potent renal prostaglandin inhibitor.
What this interaction means in plain words
Atenolol-chlorthalidone and Ketorolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atenolol-chlorthalidone belongs to Cardiovascular; Ketorolac belongs to Musculoskeletal.
Why it happens
Inhibition of renal prostaglandin synthesis causes sodium and water retention and reduces renal perfusion, opposing antihypertensive and diuretic effects.
What to do
Limit ketorolac to the shortest course possible and ensure adequate hydration. Monitor blood pressure, serum creatinine and electrolytes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atenolol-chlorthalidone
Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Frequently asked questions
Can I take Atenolol-chlorthalidone with Ketorolac?
MediHelp rates the interaction as moderate. Atenolol-chlorthalidone and Ketorolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketorolac can blunt the blood pressure-lowering effect of atenolol and chlorthalidone. Combined with a diuretic it raises the risk of acute kidney injury, especially with dehydration, because ketorolac is a potent renal prostaglandin inhibitor.
How serious is the interaction between Atenolol-chlorthalidone and Ketorolac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit ketorolac to the shortest course possible and ensure adequate hydration. Monitor blood pressure, serum creatinine and electrolytes.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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