Drug interactions
Atenolol-chlorthalidone + Meclofenamate
Severity: Moderate
Atenolol-chlorthalidone and Meclofenamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as meclofenamate can reduce the blood pressure lowering effect of atenolol and chlorthalidone. They can also reduce diuretic efficacy and increase the risk of acute kidney injury, particularly with volume depletion. Effects on potassium can vary.
What this interaction means in plain words
Atenolol-chlorthalidone and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of renal prostaglandin synthesis leads to sodium and water retention and reduced renal perfusion.
What to do
Use the lowest effective NSAID dose for the shortest time. Monitor blood pressure, renal function and potassium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atenolol-chlorthalidone
Frequently asked questions
Can I take Atenolol-chlorthalidone with Meclofenamate?
MediHelp rates the interaction as moderate. Atenolol-chlorthalidone and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as meclofenamate can reduce the blood pressure lowering effect of atenolol and chlorthalidone. They can also reduce diuretic efficacy and increase the risk of acute kidney injury, particularly with volume depletion. Effects on potassium can vary.
How serious is the interaction between Atenolol-chlorthalidone and Meclofenamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective NSAID dose for the shortest time. Monitor blood pressure, renal function and potassium.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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