Drug interactions
Atenolol-chlorthalidone + Metaproterenol
Severity: Moderate
Atenolol-chlorthalidone and Metaproterenol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metaproterenol can lower serum potassium, and chlorthalidone adds renal potassium loss, increasing the risk of hypokalemia and arrhythmia. Atenolol can also antagonize the bronchodilator effect of metaproterenol and may provoke bronchospasm in susceptible patients.
What this interaction means in plain words
Atenolol-chlorthalidone and Metaproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypokalemia, plus beta-receptor antagonism opposing the bronchodilator action.
What to do
Monitor potassium and respiratory status. Prefer a beta-1 selective blocker at the lowest dose in patients with reactive airway disease, and review the need for the combination.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atenolol-chlorthalidone
Frequently asked questions
Can I take Atenolol-chlorthalidone with Metaproterenol?
MediHelp rates the interaction as moderate. Atenolol-chlorthalidone and Metaproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metaproterenol can lower serum potassium, and chlorthalidone adds renal potassium loss, increasing the risk of hypokalemia and arrhythmia. Atenolol can also antagonize the bronchodilator effect of metaproterenol and may provoke bronchospasm in susceptible patients.
How serious is the interaction between Atenolol-chlorthalidone and Metaproterenol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor potassium and respiratory status. Prefer a beta-1 selective blocker at the lowest dose in patients with reactive airway disease, and review the need for the combination.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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