Drug interactions
Atenolol-chlorthalidone + Metipranolol
Severity: Moderate
Atenolol-chlorthalidone and Metipranolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metipranolol eye drops are absorbed systemically to some extent and can add to the effects of oral atenolol. This may cause bradycardia, hypotension, or bronchospasm in susceptible patients. Clinically important effects are uncommon.
What this interaction means in plain words
Atenolol-chlorthalidone and Metipranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic beta-adrenergic receptor blockade from systemic absorption of the ophthalmic beta-blocker.
What to do
Monitor heart rate and blood pressure after the ophthalmic beta-blocker is started. Consider a non-beta-blocker glaucoma agent if symptomatic bradycardia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atenolol-chlorthalidone
Frequently asked questions
Can I take Atenolol-chlorthalidone with Metipranolol?
MediHelp rates the interaction as moderate. Atenolol-chlorthalidone and Metipranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metipranolol eye drops are absorbed systemically to some extent and can add to the effects of oral atenolol. This may cause bradycardia, hypotension, or bronchospasm in susceptible patients. Clinically important effects are uncommon.
How serious is the interaction between Atenolol-chlorthalidone and Metipranolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure after the ophthalmic beta-blocker is started. Consider a non-beta-blocker glaucoma agent if symptomatic bradycardia occurs.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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