Drug interactions
Atenolol-chlorthalidone + Olmesartan
Severity: Moderate
Atenolol-chlorthalidone and Olmesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olmesartan adds to the blood pressure-lowering effect of atenolol and chlorthalidone, which may cause hypotension, particularly with volume depletion. Olmesartan can raise potassium and affect renal function, though chlorthalidone partly offsets this.
What this interaction means in plain words
Atenolol-chlorthalidone and Olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atenolol-chlorthalidone belongs to Cardiovascular; Olmesartan belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects from angiotensin receptor blockade, beta-blockade and diuresis, with opposing potassium effects.
What to do
Monitor blood pressure, serum potassium and creatinine after initiation or dose changes. Avoid during pregnancy because of fetal toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atenolol-chlorthalidone
Other interactions of Olmesartan
- Aliskiren + Olmesartan Contraindicated
- Olmesartan + Sparsentan Contraindicated
- Aldesleukin + Olmesartan Major
- Amifostine + Olmesartan Major
- Amiloride + Olmesartan Major
- Amlodipine-benazepril + Olmesartan Major
Frequently asked questions
Can I take Atenolol-chlorthalidone with Olmesartan?
MediHelp rates the interaction as moderate. Atenolol-chlorthalidone and Olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olmesartan adds to the blood pressure-lowering effect of atenolol and chlorthalidone, which may cause hypotension, particularly with volume depletion. Olmesartan can raise potassium and affect renal function, though chlorthalidone partly offsets this.
How serious is the interaction between Atenolol-chlorthalidone and Olmesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum potassium and creatinine after initiation or dose changes. Avoid during pregnancy because of fetal toxicity.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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