Drug interactions
Atenolol-chlorthalidone + Sildenafil
Severity: Moderate
Atenolol-chlorthalidone and Sildenafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sildenafil is a vasodilator and can lower blood pressure further in patients taking antihypertensives such as atenolol and chlorthalidone. Symptomatic hypotension or dizziness may occur, especially on starting sildenafil or in volume-depleted patients.
What this interaction means in plain words
Atenolol-chlorthalidone and Sildenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atenolol-chlorthalidone belongs to Cardiovascular; Sildenafil belongs to Genitourinary.
Why it happens
Additive vasodilatory and blood pressure lowering effects through PDE5 inhibition and antihypertensive action.
What to do
Start sildenafil at the lowest dose and monitor blood pressure and symptoms of orthostasis. Make sure the patient is not taking nitrates.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Atenolol-chlorthalidone and Sildenafil, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Atenolol-chlorthalidone
Other interactions of Sildenafil
- Amyl nitrite + Sildenafil Contraindicated
- Atazanavir + Sildenafil Contraindicated
- Cobicistat + Sildenafil Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Sildenafil Contraindicated
- Glyceryl trinitrate pr + Sildenafil Contraindicated
- Isosorbide dinitrate + Sildenafil Contraindicated
Frequently asked questions
Can I take Atenolol-chlorthalidone with Sildenafil?
MediHelp rates the interaction as moderate. Atenolol-chlorthalidone and Sildenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sildenafil is a vasodilator and can lower blood pressure further in patients taking antihypertensives such as atenolol and chlorthalidone. Symptomatic hypotension or dizziness may occur, especially on starting sildenafil or in volume-depleted patients.
How serious is the interaction between Atenolol-chlorthalidone and Sildenafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start sildenafil at the lowest dose and monitor blood pressure and symptoms of orthostasis. Make sure the patient is not taking nitrates.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
