Drug interactions
Atenolol-chlorthalidone + Telmisartan
Severity: Moderate
Atenolol-chlorthalidone and Telmisartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining these agents produces additive blood pressure lowering, which is often intended but can cause hypotension and renal function changes. Telmisartan can raise potassium while chlorthalidone lowers it, and telmisartan is contraindicated in pregnancy because of fetal toxicity.
What this interaction means in plain words
Atenolol-chlorthalidone and Telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atenolol-chlorthalidone belongs to Cardiovascular; Telmisartan belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects, with opposing effects on potassium via angiotensin receptor blockade and thiazide diuresis.
What to do
Monitor blood pressure, serum potassium, and creatinine after starting or changing doses. Avoid in pregnancy and counsel women of childbearing potential.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atenolol-chlorthalidone
Other interactions of Telmisartan
- Aliskiren + Telmisartan Contraindicated
- Sparsentan + Telmisartan Contraindicated
- Amifostine + Telmisartan Major
- Amiloride + Telmisartan Major
- Amlodipine-benazepril + Telmisartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Telmisartan Major
Frequently asked questions
Can I take Atenolol-chlorthalidone with Telmisartan?
MediHelp rates the interaction as moderate. Atenolol-chlorthalidone and Telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining these agents produces additive blood pressure lowering, which is often intended but can cause hypotension and renal function changes. Telmisartan can raise potassium while chlorthalidone lowers it, and telmisartan is contraindicated in pregnancy because of fetal toxicity.
How serious is the interaction between Atenolol-chlorthalidone and Telmisartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum potassium, and creatinine after starting or changing doses. Avoid in pregnancy and counsel women of childbearing potential.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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