Drug interactions
Atenolol-chlorthalidone + Trilostane
Severity: Moderate
Atenolol-chlorthalidone and Trilostane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trilostane inhibits adrenal steroid synthesis, including aldosterone, which promotes potassium retention. Together with chlorthalidone it may reduce thiazide-induced potassium loss but could also cause hyperkalemia or hypotension, and beta-blockers may add to potassium elevation.
What this interaction means in plain words
Atenolol-chlorthalidone and Trilostane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of 3-beta-hydroxysteroid dehydrogenase reduces aldosterone, altering potassium and sodium handling and adding to hypotensive effects.
What to do
Monitor serum potassium, sodium, and blood pressure when the combination is used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atenolol-chlorthalidone
Frequently asked questions
Can I take Atenolol-chlorthalidone with Trilostane?
MediHelp rates the interaction as moderate. Atenolol-chlorthalidone and Trilostane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trilostane inhibits adrenal steroid synthesis, including aldosterone, which promotes potassium retention. Together with chlorthalidone it may reduce thiazide-induced potassium loss but could also cause hyperkalemia or hypotension, and beta-blockers may add to potassium elevation.
How serious is the interaction between Atenolol-chlorthalidone and Trilostane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, sodium, and blood pressure when the combination is used.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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