Drug interactions
Atenolol-chlorthalidone + Umeclidinium bromide / vilanterol inhaled
Severity: Moderate
Atenolol-chlorthalidone and Umeclidinium bromide / vilanterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilanterol is a beta-agonist that can lower serum potassium and prolong QTc, effects which add to chlorthalidone-induced hypokalemia. Atenolol, a beta-1 selective blocker, may also oppose the bronchodilator effect at higher doses.
What this interaction means in plain words
Atenolol-chlorthalidone and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Beta-2 agonist-driven intracellular potassium shift adds to thiazide-like urinary potassium loss, and beta blockade antagonizes beta agonists.
What to do
Monitor serum potassium, particularly at the start of therapy or with higher doses. Correct hypokalemia, and observe respiratory status given the beta-blocker.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atenolol-chlorthalidone
Frequently asked questions
Can I take Atenolol-chlorthalidone with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as moderate. Atenolol-chlorthalidone and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vilanterol is a beta-agonist that can lower serum potassium and prolong QTc, effects which add to chlorthalidone-induced hypokalemia. Atenolol, a beta-1 selective blocker, may also oppose the bronchodilator effect at higher doses.
How serious is the interaction between Atenolol-chlorthalidone and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, particularly at the start of therapy or with higher doses. Correct hypokalemia, and observe respiratory status given the beta-blocker.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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