Drug interactions
Atenolol-chlorthalidone + Yohimbe
Severity: Moderate
Atenolol-chlorthalidone and Yohimbe: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yohimbe blocks alpha-2 receptors and raises sympathetic outflow, which can increase blood pressure and heart rate. This directly opposes the antihypertensive action of atenolol and chlorthalidone, and unopposed alpha stimulation may occur with beta-blockade.
What this interaction means in plain words
Atenolol-chlorthalidone and Yohimbe can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Alpha-2 adrenergic antagonism increases norepinephrine release, pharmacodynamically opposing antihypertensive therapy.
What to do
Advise patients to avoid yohimbe products and monitor blood pressure if they are used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atenolol-chlorthalidone
Frequently asked questions
Can I take Atenolol-chlorthalidone with Yohimbe?
MediHelp rates the interaction as moderate. Atenolol-chlorthalidone and Yohimbe can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Yohimbe blocks alpha-2 receptors and raises sympathetic outflow, which can increase blood pressure and heart rate. This directly opposes the antihypertensive action of atenolol and chlorthalidone, and unopposed alpha stimulation may occur with beta-blockade.
How serious is the interaction between Atenolol-chlorthalidone and Yohimbe?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid yohimbe products and monitor blood pressure if they are used.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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