Drug interactions
Atomoxetine + Darifenacin
Severity: Moderate
Atomoxetine and Darifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atomoxetine is metabolized chiefly by CYP2D6, which darifenacin inhibits to a modest degree. Atomoxetine exposure may rise, increasing heart rate, blood pressure and other adverse effects.
What this interaction means in plain words
Atomoxetine and Darifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atomoxetine belongs to Central Nervous System; Darifenacin belongs to Genitourinary.
Why it happens
CYP2D6 inhibition by darifenacin reduces atomoxetine clearance.
What to do
Monitor heart rate and blood pressure and for atomoxetine adverse effects. Consider a lower atomoxetine dose if tolerability problems occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Darifenacin
Other interactions of Atomoxetine
- Atomoxetine + Isocarboxazid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Atomoxetine + Rasagiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Atomoxetine with Darifenacin?
MediHelp rates the interaction as moderate. Atomoxetine and Darifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atomoxetine is metabolized chiefly by CYP2D6, which darifenacin inhibits to a modest degree. Atomoxetine exposure may rise, increasing heart rate, blood pressure and other adverse effects.
How serious is the interaction between Atomoxetine and Darifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure and for atomoxetine adverse effects. Consider a lower atomoxetine dose if tolerability problems occur.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
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