Drug interactions
Atomoxetine + Diphenhydramine
Severity: Minor
Atomoxetine and Diphenhydramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diphenhydramine is a CYP2D6 inhibitor and may modestly raise atomoxetine concentrations, mainly with regular or repeated use. Additive anticholinergic effects such as tachycardia and urinary retention may also occur.
What this interaction means in plain words
Atomoxetine and Diphenhydramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atomoxetine belongs to Central Nervous System; Diphenhydramine belongs to Respiratory.
Why it happens
Inhibition of CYP2D6-mediated atomoxetine metabolism by diphenhydramine.
What to do
Monitor heart rate, blood pressure and adverse effects if diphenhydramine is used regularly. Occasional single doses usually need no change.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Atomoxetine
- Atomoxetine + Isocarboxazid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Atomoxetine + Rasagiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
Other interactions of Diphenhydramine
Frequently asked questions
Can I take Atomoxetine with Diphenhydramine?
MediHelp rates the interaction as minor. Atomoxetine and Diphenhydramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Diphenhydramine is a CYP2D6 inhibitor and may modestly raise atomoxetine concentrations, mainly with regular or repeated use. Additive anticholinergic effects such as tachycardia and urinary retention may also occur.
How serious is the interaction between Atomoxetine and Diphenhydramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and adverse effects if diphenhydramine is used regularly. Occasional single doses usually need no change.
What other medicines interact with Atomoxetine?
MediHelp also lists interactions of Atomoxetine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Atomoxetine page.
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