Drug interactions
Atomoxetine + Epinephrine
Severity: Moderate
Atomoxetine and Epinephrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atomoxetine inhibits norepinephrine reuptake and raises blood pressure and heart rate, and systemic epinephrine adds adrenergic stimulation. The combination can cause exaggerated hypertension and tachycardia.
What this interaction means in plain words
Atomoxetine and Epinephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atomoxetine belongs to Central Nervous System; Epinephrine belongs to Endocrine.
Why it happens
Additive adrenergic effects: norepinephrine reuptake inhibition plus direct adrenergic agonism.
What to do
Monitor blood pressure and heart rate when systemic epinephrine or other vasopressors are given. Titrate vasopressor doses carefully, and do not withhold epinephrine in anaphylaxis.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atomoxetine
- Atomoxetine + Isocarboxazid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Atomoxetine + Rasagiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Frequently asked questions
Can I take Atomoxetine with Epinephrine?
MediHelp rates the interaction as moderate. Atomoxetine and Epinephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atomoxetine inhibits norepinephrine reuptake and raises blood pressure and heart rate, and systemic epinephrine adds adrenergic stimulation. The combination can cause exaggerated hypertension and tachycardia.
How serious is the interaction between Atomoxetine and Epinephrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when systemic epinephrine or other vasopressors are given. Titrate vasopressor doses carefully, and do not withhold epinephrine in anaphylaxis.
What other medicines interact with Atomoxetine?
MediHelp also lists interactions of Atomoxetine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Atomoxetine page.
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