Drug interactions
Atomoxetine + Erythromycin base
Severity: Moderate
Atomoxetine and Erythromycin base: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin prolongs the QT interval and may carry a risk of torsades de pointes, and atomoxetine has a smaller QT liability. Combined use may be additive, particularly with other risk factors such as hypokalemia or structural heart disease.
What this interaction means in plain words
Atomoxetine and Erythromycin base can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation by pharmacodynamic effects on cardiac repolarization.
What to do
Check baseline QTc and electrolytes and correct any abnormalities before combining. Consider a non-QT-prolonging antibiotic, such as amoxicillin, in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atomoxetine
- Atomoxetine + Isocarboxazid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Atomoxetine + Rasagiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Atomoxetine with Erythromycin base?
MediHelp rates the interaction as moderate. Atomoxetine and Erythromycin base can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin prolongs the QT interval and may carry a risk of torsades de pointes, and atomoxetine has a smaller QT liability. Combined use may be additive, particularly with other risk factors such as hypokalemia or structural heart disease.
How serious is the interaction between Atomoxetine and Erythromycin base?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline QTc and electrolytes and correct any abnormalities before combining. Consider a non-QT-prolonging antibiotic, such as amoxicillin, in patients with other QT risk factors.
What other medicines interact with Atomoxetine?
MediHelp also lists interactions of Atomoxetine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Atomoxetine page.
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