Drug interactions
Atomoxetine + Esketamine intranasal
Severity: Moderate
Atomoxetine and Esketamine intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Esketamine causes transient increases in blood pressure, and atomoxetine raises blood pressure and heart rate. The combination may produce greater hypertensive responses.
What this interaction means in plain words
Atomoxetine and Esketamine intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pressor effects from NMDA antagonism-related sympathetic activation and norepinephrine reuptake inhibition.
What to do
Measure blood pressure before and after esketamine dosing, and treat or withhold the dose if markedly elevated. Ensure baseline hypertension is controlled.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atomoxetine
- Atomoxetine + Isocarboxazid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Atomoxetine + Rasagiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Atomoxetine with Esketamine intranasal?
MediHelp rates the interaction as moderate. Atomoxetine and Esketamine intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Esketamine causes transient increases in blood pressure, and atomoxetine raises blood pressure and heart rate. The combination may produce greater hypertensive responses.
How serious is the interaction between Atomoxetine and Esketamine intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Measure blood pressure before and after esketamine dosing, and treat or withhold the dose if markedly elevated. Ensure baseline hypertension is controlled.
What other medicines interact with Atomoxetine?
MediHelp also lists interactions of Atomoxetine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Atomoxetine page.
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