Drug interactions
Atomoxetine + Esketamine
Severity: Moderate
Atomoxetine and Esketamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atomoxetine inhibits noradrenaline reuptake and can raise blood pressure and heart rate, and esketamine has similar transient effects. Combined use may cause greater cardiovascular stimulation.
What this interaction means in plain words
Atomoxetine and Esketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atomoxetine belongs to Central Nervous System; Esketamine belongs to Central Nervous System.
Why it happens
Additive adrenergic and pressor effects.
What to do
Monitor blood pressure and heart rate before and after esketamine dosing, and reassess the combination if sustained elevations occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esketamine
Other interactions of Atomoxetine
- Atomoxetine + Isocarboxazid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Atomoxetine + Rasagiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Atomoxetine with Esketamine?
MediHelp rates the interaction as moderate. Atomoxetine and Esketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atomoxetine inhibits noradrenaline reuptake and can raise blood pressure and heart rate, and esketamine has similar transient effects. Combined use may cause greater cardiovascular stimulation.
How serious is the interaction between Atomoxetine and Esketamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate before and after esketamine dosing, and reassess the combination if sustained elevations occur.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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