Drug interactions
Atomoxetine + Lithium
Severity: Moderate
Atomoxetine and Lithium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lithium can cause ECG changes including QT prolongation, particularly at higher serum concentrations, and atomoxetine may contribute to additive effects. Risk is greater with toxicity, renal impairment or electrolyte disturbance.
What this interaction means in plain words
Atomoxetine and Lithium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atomoxetine belongs to Central Nervous System; Lithium belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic effects on cardiac repolarization.
What to do
Monitor lithium levels and obtain an ECG in patients with cardiac risk factors. Maintain normal electrolytes and renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atomoxetine
- Atomoxetine + Isocarboxazid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Atomoxetine + Rasagiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
Other interactions of Lithium
- Lithium + Thioridazine Contraindicated
- Lithium + Vandetanib Contraindicated
- Aceclofenac + Lithium Major
- Acemetacin + Lithium Major
- Amisulpride + Lithium Major
- Amlodipine-benazepril + Lithium Major
Frequently asked questions
Can I take Atomoxetine with Lithium?
MediHelp rates the interaction as moderate. Atomoxetine and Lithium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lithium can cause ECG changes including QT prolongation, particularly at higher serum concentrations, and atomoxetine may contribute to additive effects. Risk is greater with toxicity, renal impairment or electrolyte disturbance.
How serious is the interaction between Atomoxetine and Lithium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor lithium levels and obtain an ECG in patients with cardiac risk factors. Maintain normal electrolytes and renal function.
What other medicines interact with Atomoxetine?
MediHelp also lists interactions of Atomoxetine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Atomoxetine page.
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