Drug interactions
Atomoxetine + Lorcaserin
Severity: Moderate
Atomoxetine and Lorcaserin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorcaserin inhibits CYP2D6, the main enzyme clearing atomoxetine, and may raise atomoxetine exposure. This may increase adverse effects such as tachycardia, hypertension, insomnia and gastrointestinal upset.
What this interaction means in plain words
Atomoxetine and Lorcaserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP2D6-mediated metabolism of atomoxetine.
What to do
Monitor heart rate, blood pressure and tolerability, and consider reducing the atomoxetine dose if adverse effects occur. Lorcaserin is no longer marketed in many regions.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atomoxetine
- Atomoxetine + Isocarboxazid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Atomoxetine + Rasagiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Atomoxetine with Lorcaserin?
MediHelp rates the interaction as moderate. Atomoxetine and Lorcaserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lorcaserin inhibits CYP2D6, the main enzyme clearing atomoxetine, and may raise atomoxetine exposure. This may increase adverse effects such as tachycardia, hypertension, insomnia and gastrointestinal upset.
How serious is the interaction between Atomoxetine and Lorcaserin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and tolerability, and consider reducing the atomoxetine dose if adverse effects occur. Lorcaserin is no longer marketed in many regions.
What other medicines interact with Atomoxetine?
MediHelp also lists interactions of Atomoxetine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Atomoxetine page.
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