Drug interactions
Atomoxetine + Lumefantrine
Severity: Moderate
Atomoxetine and Lumefantrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumefantrine is a CYP2D6 inhibitor and may increase atomoxetine concentrations. Lumefantrine also prolongs the QT interval, so both pharmacokinetic and pharmacodynamic concerns exist.
What this interaction means in plain words
Atomoxetine and Lumefantrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP2D6 inhibition by lumefantrine reduces atomoxetine clearance, with additional QT effects.
What to do
Monitor heart rate, blood pressure and ECG during the short antimalarial course. Reduce atomoxetine dose if adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atomoxetine
- Atomoxetine + Isocarboxazid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Atomoxetine + Rasagiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Atomoxetine with Lumefantrine?
MediHelp rates the interaction as moderate. Atomoxetine and Lumefantrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lumefantrine is a CYP2D6 inhibitor and may increase atomoxetine concentrations. Lumefantrine also prolongs the QT interval, so both pharmacokinetic and pharmacodynamic concerns exist.
How serious is the interaction between Atomoxetine and Lumefantrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG during the short antimalarial course. Reduce atomoxetine dose if adverse effects emerge.
What other medicines interact with Atomoxetine?
MediHelp also lists interactions of Atomoxetine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Atomoxetine page.
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