Drug interactions
Atomoxetine + Norepinephrine
Severity: Major
Atomoxetine and Norepinephrine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atomoxetine blocks norepinephrine reuptake and can amplify the pressor and chronotropic effects of norepinephrine infusions. This may produce exaggerated hypertension or tachyarrhythmias.
What this interaction means in plain words
Atomoxetine and Norepinephrine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Pharmacodynamic potentiation through norepinephrine transporter inhibition.
What to do
Titrate norepinephrine cautiously with continuous blood pressure and ECG monitoring, starting at low doses. Consider holding atomoxetine in patients needing vasopressors.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Atomoxetine
- Atomoxetine + Isocarboxazid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Atomoxetine + Rasagiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Atomoxetine with Norepinephrine?
MediHelp rates the interaction as major. Atomoxetine and Norepinephrine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Atomoxetine blocks norepinephrine reuptake and can amplify the pressor and chronotropic effects of norepinephrine infusions. This may produce exaggerated hypertension or tachyarrhythmias.
How serious is the interaction between Atomoxetine and Norepinephrine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate norepinephrine cautiously with continuous blood pressure and ECG monitoring, starting at low doses. Consider holding atomoxetine in patients needing vasopressors.
What other medicines interact with Atomoxetine?
MediHelp also lists interactions of Atomoxetine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Atomoxetine page.
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