Drug interactions
Atomoxetine + Olanzapine
Severity: Minor
Atomoxetine and Olanzapine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine has a low but real potential to prolong the QT interval, and atomoxetine may add slightly to this. Clinically significant arrhythmia is uncommon but is more likely with other risk factors. Both drugs may also affect heart rate and blood pressure.
What this interaction means in plain words
Atomoxetine and Olanzapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atomoxetine belongs to Central Nervous System; Olanzapine belongs to Central Nervous System.
Why it happens
Possible additive QT prolongation.
What to do
Routine dose changes are not needed; obtain an ECG if other QT-prolonging factors are present. Monitor heart rate and blood pressure.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Atomoxetine
- Atomoxetine + Isocarboxazid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Atomoxetine + Rasagiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
Other interactions of Olanzapine
Frequently asked questions
Can I take Atomoxetine with Olanzapine?
MediHelp rates the interaction as minor. Atomoxetine and Olanzapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Olanzapine has a low but real potential to prolong the QT interval, and atomoxetine may add slightly to this. Clinically significant arrhythmia is uncommon but is more likely with other risk factors. Both drugs may also affect heart rate and blood pressure.
How serious is the interaction between Atomoxetine and Olanzapine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Routine dose changes are not needed; obtain an ECG if other QT-prolonging factors are present. Monitor heart rate and blood pressure.
What other medicines interact with Atomoxetine?
MediHelp also lists interactions of Atomoxetine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Atomoxetine page.
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