Drug interactions
Atomoxetine + Pirbuterol
Severity: Moderate
Atomoxetine and Pirbuterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atomoxetine raises noradrenergic tone and can increase heart rate and blood pressure. Beta-agonists can add to these cardiovascular effects, and this is more likely with systemic than with inhaled dosing.
What this interaction means in plain words
Atomoxetine and Pirbuterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic cardiovascular stimulation from noradrenaline reuptake inhibition plus beta-adrenergic agonism.
What to do
Monitor heart rate and blood pressure when starting or adjusting either drug, especially if pirbuterol is used frequently. Reassess the need for beta-agonist doses if palpitations or tachycardia occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atomoxetine
- Atomoxetine + Isocarboxazid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Atomoxetine + Rasagiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Atomoxetine with Pirbuterol?
MediHelp rates the interaction as moderate. Atomoxetine and Pirbuterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atomoxetine raises noradrenergic tone and can increase heart rate and blood pressure. Beta-agonists can add to these cardiovascular effects, and this is more likely with systemic than with inhaled dosing.
How serious is the interaction between Atomoxetine and Pirbuterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when starting or adjusting either drug, especially if pirbuterol is used frequently. Reassess the need for beta-agonist doses if palpitations or tachycardia occur.
What other medicines interact with Atomoxetine?
MediHelp also lists interactions of Atomoxetine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Atomoxetine page.
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