Drug interactions
Atomoxetine + Saquinavir
Severity: Major
Atomoxetine and Saquinavir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir-boosted saquinavir prolongs the QT and PR intervals and is labeled to be avoided with other QT-prolonging drugs. Atomoxetine may add a small QT effect, and ritonavir may also raise atomoxetine levels through CYP2D6 inhibition.
What this interaction means in plain words
Atomoxetine and Saquinavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation, with possible increased atomoxetine exposure from ritonavir.
What to do
Avoid if possible, or obtain a baseline ECG and monitor QTc and electrolytes. Use a lower atomoxetine dose and monitor heart rate and blood pressure.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Atomoxetine and Saquinavir, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Atomoxetine
- Atomoxetine + Isocarboxazid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Atomoxetine + Rasagiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Atomoxetine with Saquinavir?
MediHelp rates the interaction as major. Atomoxetine and Saquinavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ritonavir-boosted saquinavir prolongs the QT and PR intervals and is labeled to be avoided with other QT-prolonging drugs. Atomoxetine may add a small QT effect, and ritonavir may also raise atomoxetine levels through CYP2D6 inhibition.
How serious is the interaction between Atomoxetine and Saquinavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible, or obtain a baseline ECG and monitor QTc and electrolytes. Use a lower atomoxetine dose and monitor heart rate and blood pressure.
What other medicines interact with Atomoxetine?
MediHelp also lists interactions of Atomoxetine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Atomoxetine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
