Drug interactions
Atracurium + Buprenorphine long-acting
Severity: Moderate
Atracurium and Buprenorphine long-acting: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids such as buprenorphine can cause respiratory depression and may add to the effects of neuromuscular blockers. Residual respiratory depression or prolonged weakness can occur after surgery, but atracurium is used only under controlled, ventilated conditions.
What this interaction means in plain words
Atracurium and Buprenorphine long-acting can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive respiratory depression and possible enhancement of neuromuscular blockade.
What to do
Monitor neuromuscular function with a train-of-four and ventilation during anesthesia. Observe the patient for residual weakness and respiratory depression during recovery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atracurium
Frequently asked questions
Can I take Atracurium with Buprenorphine long-acting?
MediHelp rates the interaction as moderate. Atracurium and Buprenorphine long-acting can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioids such as buprenorphine can cause respiratory depression and may add to the effects of neuromuscular blockers. Residual respiratory depression or prolonged weakness can occur after surgery, but atracurium is used only under controlled, ventilated conditions.
How serious is the interaction between Atracurium and Buprenorphine long-acting?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular function with a train-of-four and ventilation during anesthesia. Observe the patient for residual weakness and respiratory depression during recovery.
What other medicines interact with Atracurium?
MediHelp also lists interactions of Atracurium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Benzhydrocodone / acetaminophen. The full list is on the Atracurium page.
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