Drug interactions
Atracurium + Echothiophate iodide
Severity: Moderate
Atracurium and Echothiophate iodide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Echothiophate is an irreversible cholinesterase inhibitor used in the eye, and some systemic absorption occurs. It may diminish the effect of atracurium, though atracurium is mainly cleared by Hofmann elimination and ester hydrolysis rather than cholinesterase.
What this interaction means in plain words
Atracurium and Echothiophate iodide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Raised acetylcholine from cholinesterase inhibition opposes competitive neuromuscular blockade.
What to do
Alert the anesthesia team to echothiophate use and monitor train-of-four, adjusting atracurium dose to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atracurium
Frequently asked questions
Can I take Atracurium with Echothiophate iodide?
MediHelp rates the interaction as moderate. Atracurium and Echothiophate iodide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Echothiophate is an irreversible cholinesterase inhibitor used in the eye, and some systemic absorption occurs. It may diminish the effect of atracurium, though atracurium is mainly cleared by Hofmann elimination and ester hydrolysis rather than cholinesterase.
How serious is the interaction between Atracurium and Echothiophate iodide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Alert the anesthesia team to echothiophate use and monitor train-of-four, adjusting atracurium dose to response.
What other medicines interact with Atracurium?
MediHelp also lists interactions of Atracurium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Benzhydrocodone / acetaminophen. The full list is on the Atracurium page.
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