Drug interactions
Atracurium + Fentanyl
Severity: Minor
Atracurium and Fentanyl: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atracurium is a neuromuscular blocker used with anesthesia and has no CNS depressant action itself. Fentanyl is routinely combined with it in anesthesia under ventilatory control, and the main concern is respiratory depression if ventilation is not supported.
What this interaction means in plain words
Atracurium and Fentanyl have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atracurium belongs to Musculoskeletal; Fentanyl belongs to Musculoskeletal.
Why it happens
No significant pharmacokinetic interaction; fentanyl may add mild bradycardia or hypotension in anesthetic settings.
What to do
Use only where ventilation can be supported and monitor heart rate and blood pressure during anesthesia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Other interactions of Atracurium
Frequently asked questions
Can I take Atracurium with Fentanyl?
MediHelp rates the interaction as minor. Atracurium and Fentanyl have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Atracurium is a neuromuscular blocker used with anesthesia and has no CNS depressant action itself. Fentanyl is routinely combined with it in anesthesia under ventilatory control, and the main concern is respiratory depression if ventilation is not supported.
How serious is the interaction between Atracurium and Fentanyl?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only where ventilation can be supported and monitor heart rate and blood pressure during anesthesia.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
