Drug interactions
Atracurium + Hydrocortisone
Severity: Moderate
Atracurium and Hydrocortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids given with nondepolarizing neuromuscular blockers, particularly in critically ill patients, are associated with acute myopathy and prolonged weakness. Neuromuscular recovery may be delayed.
What this interaction means in plain words
Atracurium and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atracurium belongs to Musculoskeletal; Hydrocortisone belongs to Endocrine.
Why it happens
Additive pharmacodynamic effect on muscle, with steroid-related myopathy compounding neuromuscular blockade.
What to do
Use the lowest effective dose and shortest duration of the blocker, monitor neuromuscular function with train-of-four, and assess for weakness or raised creatine kinase.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Atracurium
Frequently asked questions
Can I take Atracurium with Hydrocortisone?
MediHelp rates the interaction as moderate. Atracurium and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids given with nondepolarizing neuromuscular blockers, particularly in critically ill patients, are associated with acute myopathy and prolonged weakness. Neuromuscular recovery may be delayed.
How serious is the interaction between Atracurium and Hydrocortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective dose and shortest duration of the blocker, monitor neuromuscular function with train-of-four, and assess for weakness or raised creatine kinase.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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