Drug interactions
Atracurium + Incobotulinumtoxina
Severity: Moderate
Atracurium and Incobotulinumtoxina: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Neuromuscular blockers can augment the effect of botulinum toxins, leading to excessive muscle weakness. Systemic spread of weakness, including swallowing and breathing difficulty, could be heightened.
What this interaction means in plain words
Atracurium and Incobotulinumtoxina can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive impairment of neuromuscular transmission, presynaptic by botulinum toxin and postsynaptic by atracurium.
What to do
Avoid giving botulinum toxin close to neuromuscular blocker use where possible, and monitor for generalized weakness and respiratory or swallowing difficulty.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atracurium
Frequently asked questions
Can I take Atracurium with Incobotulinumtoxina?
MediHelp rates the interaction as moderate. Atracurium and Incobotulinumtoxina can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Neuromuscular blockers can augment the effect of botulinum toxins, leading to excessive muscle weakness. Systemic spread of weakness, including swallowing and breathing difficulty, could be heightened.
How serious is the interaction between Atracurium and Incobotulinumtoxina?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving botulinum toxin close to neuromuscular blocker use where possible, and monitor for generalized weakness and respiratory or swallowing difficulty.
What other medicines interact with Atracurium?
MediHelp also lists interactions of Atracurium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Benzhydrocodone / acetaminophen. The full list is on the Atracurium page.
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