Drug interactions
Atracurium + Orphenadrine
Severity: Minor
Atracurium and Orphenadrine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Orphenadrine is a centrally acting muscle relaxant with anticholinergic activity, and may add modestly to muscle weakness with neuromuscular blockers. Evidence of a clinically significant effect with atracurium is limited.
What this interaction means in plain words
Atracurium and Orphenadrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive skeletal muscle relaxation and weak anticholinergic effects; not firmly established.
What to do
Monitor neuromuscular blockade with train-of-four and titrate atracurium to effect in patients taking orphenadrine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Atracurium
Frequently asked questions
Can I take Atracurium with Orphenadrine?
MediHelp rates the interaction as minor. Atracurium and Orphenadrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Orphenadrine is a centrally acting muscle relaxant with anticholinergic activity, and may add modestly to muscle weakness with neuromuscular blockers. Evidence of a clinically significant effect with atracurium is limited.
How serious is the interaction between Atracurium and Orphenadrine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular blockade with train-of-four and titrate atracurium to effect in patients taking orphenadrine.
What other medicines interact with Atracurium?
MediHelp also lists interactions of Atracurium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Benzhydrocodone / acetaminophen. The full list is on the Atracurium page.
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