Drug interactions
Atracurium + Prabotulinumtoxina
Severity: Moderate
Atracurium and Prabotulinumtoxina: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Neuromuscular blockers can add to the paralytic effect of botulinum toxin. This may cause excessive muscle weakness, including at sites distant from the injection, with possible swallowing or breathing difficulty.
What this interaction means in plain words
Atracurium and Prabotulinumtoxina can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive neuromuscular blockade, presynaptic inhibition of acetylcholine release by the toxin plus postsynaptic receptor blockade by atracurium.
What to do
Monitor for generalized weakness, dysphagia and respiratory compromise after botulinum toxin treatment when a neuromuscular blocker is used. Use reduced or titrated blocker doses with neuromuscular monitoring in recently treated patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atracurium
Frequently asked questions
Can I take Atracurium with Prabotulinumtoxina?
MediHelp rates the interaction as moderate. Atracurium and Prabotulinumtoxina can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Neuromuscular blockers can add to the paralytic effect of botulinum toxin. This may cause excessive muscle weakness, including at sites distant from the injection, with possible swallowing or breathing difficulty.
How serious is the interaction between Atracurium and Prabotulinumtoxina?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for generalized weakness, dysphagia and respiratory compromise after botulinum toxin treatment when a neuromuscular blocker is used. Use reduced or titrated blocker doses with neuromuscular monitoring in recently treated patients.
What other medicines interact with Atracurium?
MediHelp also lists interactions of Atracurium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Benzhydrocodone / acetaminophen. The full list is on the Atracurium page.
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