Drug interactions
Atracurium + Sufentanil sl
Severity: Major
Atracurium and Sufentanil sl: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sufentanil causes respiratory depression, sedation and hypotension that add to the effects of a neuromuscular blocker. Residual blockade plus opioid effect can compromise ventilation.
What this interaction means in plain words
Atracurium and Sufentanil sl can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive respiratory depression from central opioid effect and peripheral neuromuscular blockade.
What to do
Use only with airway and ventilatory support and monitor neuromuscular function, respiration and blood pressure. Use the lowest effective doses.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Atracurium
Frequently asked questions
Can I take Atracurium with Sufentanil sl?
MediHelp rates the interaction as major. Atracurium and Sufentanil sl can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sufentanil causes respiratory depression, sedation and hypotension that add to the effects of a neuromuscular blocker. Residual blockade plus opioid effect can compromise ventilation.
How serious is the interaction between Atracurium and Sufentanil sl?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only with airway and ventilatory support and monitor neuromuscular function, respiration and blood pressure. Use the lowest effective doses.
What other medicines interact with Atracurium?
MediHelp also lists interactions of Atracurium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Benzhydrocodone / acetaminophen. The full list is on the Atracurium page.
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