Drug interactions
Atracurium + Tobramycin inhaled
Severity: Minor
Atracurium and Tobramycin inhaled: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic aminoglycosides potentiate nondepolarizing neuromuscular blockers, causing prolonged paralysis. Systemic absorption of inhaled tobramycin is low, so the effect is likely small, but it is possible with high doses or impaired renal function.
What this interaction means in plain words
Atracurium and Tobramycin inhaled have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Aminoglycosides reduce presynaptic acetylcholine release and postsynaptic sensitivity, enhancing neuromuscular blockade.
What to do
Monitor neuromuscular function with a train-of-four during surgery and ensure full recovery before extubation. Take extra care in patients with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Atracurium and Tobramycin inhaled, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Atracurium
Frequently asked questions
Can I take Atracurium with Tobramycin inhaled?
MediHelp rates the interaction as minor. Atracurium and Tobramycin inhaled have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Systemic aminoglycosides potentiate nondepolarizing neuromuscular blockers, causing prolonged paralysis. Systemic absorption of inhaled tobramycin is low, so the effect is likely small, but it is possible with high doses or impaired renal function.
How serious is the interaction between Atracurium and Tobramycin inhaled?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular function with a train-of-four during surgery and ensure full recovery before extubation. Take extra care in patients with renal impairment.
What other medicines interact with Atracurium?
MediHelp also lists interactions of Atracurium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Benzhydrocodone / acetaminophen. The full list is on the Atracurium page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
