Drug interactions
Auranofin + Tofacitinib
Severity: Moderate
Auranofin and Tofacitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Auranofin is an immunomodulating gold compound that can cause bone marrow suppression. Combined with tofacitinib it may add to infection and cytopenia risk.
What this interaction means in plain words
Auranofin and Tofacitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Auranofin belongs to Musculoskeletal; Tofacitinib belongs to Musculoskeletal.
Why it happens
Additive immunosuppression and potential myelosuppression.
What to do
Monitor blood counts and infection signs regularly. Reduce or stop one agent if cytopenias or serious infection occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tofacitinib
- Baricitinib + Tofacitinib Contraindicated
- Cladribine + Tofacitinib Contraindicated
- Tofacitinib + Upadacitinib Contraindicated
- Abatacept + Tofacitinib Major
- Anti-thymocyte + Tofacitinib Major
- Antithymocyte globulin equine + Tofacitinib Major
Other interactions of Auranofin
- Auranofin + Ocrelizumab Moderate
Frequently asked questions
Can I take Auranofin with Tofacitinib?
MediHelp rates the interaction as moderate. Auranofin and Tofacitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Auranofin is an immunomodulating gold compound that can cause bone marrow suppression. Combined with tofacitinib it may add to infection and cytopenia risk.
How serious is the interaction between Auranofin and Tofacitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and infection signs regularly. Reduce or stop one agent if cytopenias or serious infection occur.
What other medicines interact with Tofacitinib?
MediHelp also lists interactions of Tofacitinib with, for example, Baricitinib, Cladribine, Upadacitinib. The full list is on the Tofacitinib page.
Full monographs, dosing and an interaction checker in the MediHelp app
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