Drug interactions
Azapropazone + Heparin
Severity: Major
Azapropazone and Heparin: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Azapropazone is an NSAID that impairs platelet function and can cause gastrointestinal ulceration, so combined with heparin the bleeding risk is increased. Protein-binding displacement is claimed but is of doubtful importance for heparin.
What this interaction means in plain words
Azapropazone and Heparin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive effects on hemostasis from NSAID platelet inhibition and heparin anticoagulation, plus NSAID-related gastric mucosal injury.
What to do
Avoid the combination where possible and choose a non-NSAID analgesic such as paracetamol. If it is unavoidable, monitor for bleeding and check aPTT or anti-Xa and hemoglobin.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Heparin
- Defibrotide + Heparin Contraindicated
- Heparin + Ketorolac Contraindicated
- Heparin + Oritavancin Contraindicated
- Acemetacin + Heparin Major
- Acetylsalicylic acid + Heparin Major
- Alteplase + Heparin Major
Frequently asked questions
Can I take Azapropazone with Heparin?
MediHelp rates the interaction as major. Azapropazone and Heparin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Azapropazone is an NSAID that impairs platelet function and can cause gastrointestinal ulceration, so combined with heparin the bleeding risk is increased. Protein-binding displacement is claimed but is of doubtful importance for heparin.
How serious is the interaction between Azapropazone and Heparin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and choose a non-NSAID analgesic such as paracetamol. If it is unavoidable, monitor for bleeding and check aPTT or anti-Xa and hemoglobin.
What other medicines interact with Heparin?
MediHelp also lists interactions of Heparin with, for example, Defibrotide, Ketorolac, Oritavancin. The full list is on the Heparin page.
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