Drug interactions
Azilsartan medoxomil + Lithium
Severity: Major
Azilsartan medoxomil and Lithium: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Angiotensin II receptor blockers can reduce renal lithium clearance and raise serum lithium. This may lead to lithium toxicity with tremor, confusion and arrhythmia.
What this interaction means in plain words
Azilsartan medoxomil and Lithium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Azilsartan medoxomil belongs to Cardiovascular; Lithium belongs to Central Nervous System.
Why it happens
Reduced renal sodium and lithium excretion increases proximal tubular lithium reabsorption.
What to do
Check lithium levels before and shortly after starting or changing the azilsartan dose, and reduce lithium dose as needed. Watch for toxicity signs and renal function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Azilsartan medoxomil
Other interactions of Lithium
- Lithium + Thioridazine Contraindicated
- Lithium + Vandetanib Contraindicated
- Aceclofenac + Lithium Major
- Acemetacin + Lithium Major
- Amisulpride + Lithium Major
- Amlodipine-benazepril + Lithium Major
Frequently asked questions
Can I take Azilsartan medoxomil with Lithium?
MediHelp rates the interaction as major. Azilsartan medoxomil and Lithium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Angiotensin II receptor blockers can reduce renal lithium clearance and raise serum lithium. This may lead to lithium toxicity with tremor, confusion and arrhythmia.
How serious is the interaction between Azilsartan medoxomil and Lithium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check lithium levels before and shortly after starting or changing the azilsartan dose, and reduce lithium dose as needed. Watch for toxicity signs and renal function.
What other medicines interact with Azilsartan medoxomil?
MediHelp also lists interactions of Azilsartan medoxomil with, for example, Aliskiren. The full list is on the Azilsartan medoxomil page.
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