Drug interactions
Baricitinib + Bcg vaccine live
Severity: Contraindicated
Baricitinib and Bcg vaccine live: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Baricitinib-related immunosuppression raises the risk of disseminated BCG infection from the live vaccine and may reduce its effectiveness.
What this interaction means in plain words
Baricitinib and Bcg vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
JAK inhibition-induced immunosuppression allows uncontrolled replication of live attenuated bacteria.
What to do
Do not give BCG vaccine during baricitinib treatment. Vaccinate before starting therapy where indicated, following current guidelines.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Baricitinib
- Adenovirus types 4 and 7 live + Baricitinib Contraindicated
- Baricitinib + Tofacitinib Contraindicated
- Baricitinib + Upadacitinib Contraindicated
- Abatacept + Baricitinib Major
- Adalimumab + Baricitinib Major
- Ado-trastuzumab + Baricitinib Major
Frequently asked questions
Can I take Baricitinib with Bcg vaccine live?
MediHelp rates the interaction as contraindicated. Baricitinib and Bcg vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Baricitinib-related immunosuppression raises the risk of disseminated BCG infection from the live vaccine and may reduce its effectiveness.
How serious is the interaction between Baricitinib and Bcg vaccine live?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give BCG vaccine during baricitinib treatment. Vaccinate before starting therapy where indicated, following current guidelines.
What other medicines interact with Baricitinib?
MediHelp also lists interactions of Baricitinib with, for example, Adenovirus types 4 and 7 live, Tofacitinib, Upadacitinib. The full list is on the Baricitinib page.
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