Drug interactions
Bazedoxifene / conjugated estrogens + Cefalexin
Severity: Minor
Bazedoxifene / conjugated estrogens and Cefalexin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antibiotics were once thought to reduce enterohepatic recycling of estrogens by altering gut flora. Evidence of a clinically meaningful loss of estrogen effect with non-enzyme-inducing antibiotics such as cefalexin is lacking, and the risk is considered very low.
What this interaction means in plain words
Bazedoxifene / conjugated estrogens and Cefalexin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical reduction in gut bacterial deconjugation and enterohepatic recirculation of estrogens.
What to do
No action is usually needed. Report any unexpected vaginal bleeding or loss of efficacy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cefalexin
- Amikacin + Cefalexin Moderate
- Avelumab + Cefalexin Moderate
- Balstilimab + Cefalexin Moderate
- Bcg vaccine live + Cefalexin Moderate
- Cefalexin + Cholera vaccine Moderate
- Cefalexin + Gentamicin Moderate
Frequently asked questions
Can I take Bazedoxifene / conjugated estrogens with Cefalexin?
MediHelp rates the interaction as minor. Bazedoxifene / conjugated estrogens and Cefalexin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antibiotics were once thought to reduce enterohepatic recycling of estrogens by altering gut flora. Evidence of a clinically meaningful loss of estrogen effect with non-enzyme-inducing antibiotics such as cefalexin is lacking, and the risk is considered very low.
How serious is the interaction between Bazedoxifene / conjugated estrogens and Cefalexin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is usually needed. Report any unexpected vaginal bleeding or loss of efficacy.
What other medicines interact with Cefalexin?
MediHelp also lists interactions of Cefalexin with, for example, Amikacin, Avelumab, Balstilimab. The full list is on the Cefalexin page.
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