Drug interactions
Bazedoxifene / conjugated estrogens + Diltiazem
Severity: Minor
Bazedoxifene / conjugated estrogens and Diltiazem: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diltiazem may increase exposure to conjugated estrogens and bazedoxifene by reducing their metabolism. This could increase estrogen-related adverse effects such as breast tenderness and endometrial stimulation.
What this interaction means in plain words
Bazedoxifene / conjugated estrogens and Diltiazem have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of CYP3A4 by diltiazem reduces estrogen metabolism.
What to do
Monitor for estrogenic adverse effects and adjust the dose of the estrogen product if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Frequently asked questions
Can I take Bazedoxifene / conjugated estrogens with Diltiazem?
MediHelp rates the interaction as minor. Bazedoxifene / conjugated estrogens and Diltiazem have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Diltiazem may increase exposure to conjugated estrogens and bazedoxifene by reducing their metabolism. This could increase estrogen-related adverse effects such as breast tenderness and endometrial stimulation.
How serious is the interaction between Bazedoxifene / conjugated estrogens and Diltiazem?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for estrogenic adverse effects and adjust the dose of the estrogen product if they occur.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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