Drug interactions
Bazedoxifene / conjugated estrogens + Heparin
Severity: Major
Bazedoxifene / conjugated estrogens and Heparin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estrogens and bazedoxifene increase thromboembolic risk, which works against the purpose of anticoagulation. Patients needing heparin for active thrombosis should not take these agents.
What this interaction means in plain words
Bazedoxifene / conjugated estrogens and Heparin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Prothrombotic effects of estrogens and SERM opposing anticoagulation.
What to do
Stop the estrogen product in patients with active venous thromboembolism needing heparin; reassess its need afterwards.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Heparin
- Defibrotide + Heparin Contraindicated
- Heparin + Ketorolac Contraindicated
- Heparin + Oritavancin Contraindicated
- Acemetacin + Heparin Major
- Acetylsalicylic acid + Heparin Major
- Alteplase + Heparin Major
Frequently asked questions
Can I take Bazedoxifene / conjugated estrogens with Heparin?
MediHelp rates the interaction as major. Bazedoxifene / conjugated estrogens and Heparin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Estrogens and bazedoxifene increase thromboembolic risk, which works against the purpose of anticoagulation. Patients needing heparin for active thrombosis should not take these agents.
How serious is the interaction between Bazedoxifene / conjugated estrogens and Heparin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Stop the estrogen product in patients with active venous thromboembolism needing heparin; reassess its need afterwards.
What other medicines interact with Heparin?
MediHelp also lists interactions of Heparin with, for example, Defibrotide, Ketorolac, Oritavancin. The full list is on the Heparin page.
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