Drug interactions
Belladonna alkaloids + Pimozide
Severity: Moderate
Belladonna alkaloids and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Belladonna alkaloids have antimuscarinic activity, and pimozide also has some anticholinergic properties, so the combination can add to dry mouth, urinary retention, constipation, blurred vision and confusion. Reduced gut motility may also change oral absorption of pimozide.
What this interaction means in plain words
Belladonna alkaloids and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive anticholinergic effects, with possible altered gastrointestinal absorption of oral pimozide due to slowed motility.
What to do
Monitor for anticholinergic adverse effects, particularly in elderly patients, and reduce the anticholinergic dose if they appear. Watch for loss of symptom control or for pimozide adverse effects if either drug is started or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Belladonna alkaloids with Pimozide?
MediHelp rates the interaction as moderate. Belladonna alkaloids and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Belladonna alkaloids have antimuscarinic activity, and pimozide also has some anticholinergic properties, so the combination can add to dry mouth, urinary retention, constipation, blurred vision and confusion. Reduced gut motility may also change oral absorption of pimozide.
How serious is the interaction between Belladonna alkaloids and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects, particularly in elderly patients, and reduce the anticholinergic dose if they appear. Watch for loss of symptom control or for pimozide adverse effects if either drug is started or stopped.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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