Drug interactions
Belladonna and opium + Carbidopa-entacapone-levodopa
Severity: Moderate
Belladonna and opium and Carbidopa-entacapone-levodopa: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The belladonna component slows gastric emptying and may delay levodopa absorption. The opium component adds sedation and constipation, which are problematic in Parkinson's disease, and combined use may increase confusion.
What this interaction means in plain words
Belladonna and opium and Carbidopa-entacapone-levodopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Anticholinergic delay of levodopa absorption plus additive CNS depression from opioid.
What to do
Monitor motor response, sedation and bowel function. Adjust therapy if levodopa effect becomes erratic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbidopa-entacapone-levodopa
- Carbidopa-entacapone-levodopa + Isocarboxazid Contraindicated
- Carbidopa-entacapone-levodopa + Phenelzine Contraindicated
- Carbidopa-entacapone-levodopa + Selegiline transdermal Contraindicated
- Carbidopa-entacapone-levodopa + Tranylcypromine Contraindicated
- Amisulpride + Carbidopa-entacapone-levodopa Major
- Asenapine transdermal + Carbidopa-entacapone-levodopa Major
Frequently asked questions
Can I take Belladonna and opium with Carbidopa-entacapone-levodopa?
MediHelp rates the interaction as moderate. Belladonna and opium and Carbidopa-entacapone-levodopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The belladonna component slows gastric emptying and may delay levodopa absorption. The opium component adds sedation and constipation, which are problematic in Parkinson's disease, and combined use may increase confusion.
How serious is the interaction between Belladonna and opium and Carbidopa-entacapone-levodopa?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor motor response, sedation and bowel function. Adjust therapy if levodopa effect becomes erratic.
What other medicines interact with Carbidopa-entacapone-levodopa?
MediHelp also lists interactions of Carbidopa-entacapone-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-entacapone-levodopa page.
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