Drug interactions
Belladonna and opium + Darifenacin
Severity: Moderate
Belladonna and opium and Darifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Belladonna contributes antimuscarinic activity and opium adds opioid-related slowing of gut and bladder function. Combined with darifenacin, the risk of constipation, urinary retention, ileus and sedation is increased.
What this interaction means in plain words
Belladonna and opium and Darifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects with opioid-induced reduction in smooth muscle motility and CNS depression.
What to do
Monitor bowel and bladder function and level of sedation, and avoid use in patients with urinary retention or reduced gastric motility.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Darifenacin
Frequently asked questions
Can I take Belladonna and opium with Darifenacin?
MediHelp rates the interaction as moderate. Belladonna and opium and Darifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Belladonna contributes antimuscarinic activity and opium adds opioid-related slowing of gut and bladder function. Combined with darifenacin, the risk of constipation, urinary retention, ileus and sedation is increased.
How serious is the interaction between Belladonna and opium and Darifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor bowel and bladder function and level of sedation, and avoid use in patients with urinary retention or reduced gastric motility.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
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