Drug interactions
Belladonna and opium + Dextroamphetamine
Severity: Minor
Belladonna and opium and Dextroamphetamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opium causes sedation and respiratory depression, whereas dextroamphetamine is stimulating. The stimulant may mask sedation without reversing respiratory depression. Belladonna's anticholinergic effects may add to tachycardia from the stimulant.
What this interaction means in plain words
Belladonna and opium and Dextroamphetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing CNS effects, plus additive anticholinergic and sympathomimetic effects on heart rate.
What to do
Monitor sedation, respiratory rate and heart rate. Do not use stimulant-related alertness as a sign that opioid dosing is safe.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Belladonna and opium with Dextroamphetamine?
MediHelp rates the interaction as minor. Belladonna and opium and Dextroamphetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Opium causes sedation and respiratory depression, whereas dextroamphetamine is stimulating. The stimulant may mask sedation without reversing respiratory depression. Belladonna's anticholinergic effects may add to tachycardia from the stimulant.
How serious is the interaction between Belladonna and opium and Dextroamphetamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, respiratory rate and heart rate. Do not use stimulant-related alertness as a sign that opioid dosing is safe.
What other medicines interact with Dextroamphetamine?
MediHelp also lists interactions of Dextroamphetamine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Dextroamphetamine page.
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