Drug interactions
Belladonna and opium + Ketamine
Severity: Moderate
Belladonna and opium and Ketamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The opium component adds opioid sedation and respiratory depression to ketamine, and belladonna adds anticholinergic effects such as tachycardia and confusion. The combination may cause deeper sedation and agitation or delirium.
What this interaction means in plain words
Belladonna and opium and Ketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS and respiratory depression from opioid agonism plus anticholinergic effects.
What to do
Monitor respiration, sedation and heart rate, and reduce doses as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketamine
Frequently asked questions
Can I take Belladonna and opium with Ketamine?
MediHelp rates the interaction as moderate. Belladonna and opium and Ketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The opium component adds opioid sedation and respiratory depression to ketamine, and belladonna adds anticholinergic effects such as tachycardia and confusion. The combination may cause deeper sedation and agitation or delirium.
How serious is the interaction between Belladonna and opium and Ketamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiration, sedation and heart rate, and reduce doses as needed.
What other medicines interact with Ketamine?
MediHelp also lists interactions of Ketamine with, for example, Benzhydrocodone / acetaminophen, Brexanolone, Buprenorphine buccal. The full list is on the Ketamine page.
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