Drug interactions
Bemiparin + Ethinyl estradiol-levonorgestrel
Severity: Moderate
Bemiparin and Ethinyl estradiol-levonorgestrel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estrogen-containing contraceptives raise thrombotic risk, which opposes the aim of heparin anticoagulation. Patients needing treatment for thrombosis generally should not use combined hormonal contraception.
What this interaction means in plain words
Bemiparin and Ethinyl estradiol-levonorgestrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Estrogen increases procoagulant factors, pharmacodynamically opposing the anticoagulant effect of bemiparin.
What to do
Avoid estrogen-containing contraceptives in patients with active thromboembolism; use a non-estrogen method. Review the need for estrogen when prophylactic dosing is used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-levonorgestrel
- Ethinyl estradiol-levonorgestrel + Fezolinetant Contraindicated
- Ethinyl estradiol-levonorgestrel + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-levonorgestrel + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-levonorgestrel Major
- Amobarbital + Ethinyl estradiol-levonorgestrel Major
- Anastrozole + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Bemiparin with Ethinyl estradiol-levonorgestrel?
MediHelp rates the interaction as moderate. Bemiparin and Ethinyl estradiol-levonorgestrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Estrogen-containing contraceptives raise thrombotic risk, which opposes the aim of heparin anticoagulation. Patients needing treatment for thrombosis generally should not use combined hormonal contraception.
How serious is the interaction between Bemiparin and Ethinyl estradiol-levonorgestrel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid estrogen-containing contraceptives in patients with active thromboembolism; use a non-estrogen method. Review the need for estrogen when prophylactic dosing is used.
What other medicines interact with Ethinyl estradiol-levonorgestrel?
MediHelp also lists interactions of Ethinyl estradiol-levonorgestrel with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-levonorgestrel page.
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