Drug interactions
Bendamustine + Glecaprevir / pibrentasvir
Severity: Minor
Bendamustine and Glecaprevir / pibrentasvir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glecaprevir and pibrentasvir inhibit P-glycoprotein, which could theoretically increase bendamustine exposure. Bendamustine is mainly hydrolyzed, so the effect is likely small.
What this interaction means in plain words
Bendamustine and Glecaprevir / pibrentasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
P-glycoprotein inhibition by glecaprevir/pibrentasvir may increase bendamustine exposure.
What to do
No dose change is routinely needed; monitor blood counts for increased myelosuppression.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bendamustine
Frequently asked questions
Can I take Bendamustine with Glecaprevir / pibrentasvir?
MediHelp rates the interaction as minor. Bendamustine and Glecaprevir / pibrentasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glecaprevir and pibrentasvir inhibit P-glycoprotein, which could theoretically increase bendamustine exposure. Bendamustine is mainly hydrolyzed, so the effect is likely small.
How serious is the interaction between Bendamustine and Glecaprevir / pibrentasvir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely needed; monitor blood counts for increased myelosuppression.
What other medicines interact with Bendamustine?
MediHelp also lists interactions of Bendamustine with, for example, Axicabtagene ciloleucel, Brexucabtagene autoleucel, Chlorambucil. The full list is on the Bendamustine page.
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