Drug interactions
Bendamustine + Influenza virus vaccine adjuvanted
Severity: Moderate
Bendamustine and Influenza virus vaccine adjuvanted: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bendamustine-induced lymphodepletion can reduce the immune response to the adjuvanted H5N1 influenza vaccine. Protection may be incomplete even with the adjuvant.
What this interaction means in plain words
Bendamustine and Influenza virus vaccine adjuvanted can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cytotoxic suppression of B and T lymphocytes impairs antibody production after vaccination.
What to do
Vaccinate before chemotherapy when possible, or time doses away from treatment nadirs; consider that the response may be inadequate and keep other protective measures in place.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bendamustine
Frequently asked questions
Can I take Bendamustine with Influenza virus vaccine adjuvanted?
MediHelp rates the interaction as moderate. Bendamustine and Influenza virus vaccine adjuvanted can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bendamustine-induced lymphodepletion can reduce the immune response to the adjuvanted H5N1 influenza vaccine. Protection may be incomplete even with the adjuvant.
How serious is the interaction between Bendamustine and Influenza virus vaccine adjuvanted?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate before chemotherapy when possible, or time doses away from treatment nadirs; consider that the response may be inadequate and keep other protective measures in place.
What other medicines interact with Bendamustine?
MediHelp also lists interactions of Bendamustine with, for example, Axicabtagene ciloleucel, Brexucabtagene autoleucel, Chlorambucil. The full list is on the Bendamustine page.
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