Drug interactions
Bendroflumethiazide + Captopril
Severity: Moderate
Bendroflumethiazide and Captopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics and ACE inhibitors are often combined deliberately for additive blood pressure control. First-dose hypotension and renal function decline may occur, particularly in volume-depleted patients, and ACE inhibition counteracts thiazide-induced potassium loss.
What this interaction means in plain words
Bendroflumethiazide and Captopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antihypertensive effect from diuresis-related volume reduction and renin-angiotensin blockade.
What to do
Start with low doses, and monitor blood pressure, serum creatinine and electrolytes after initiation or dose changes. Consider reducing or holding the diuretic before starting captopril in volume-depleted patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Bendroflumethiazide and Captopril, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Frequently asked questions
Can I take Bendroflumethiazide with Captopril?
MediHelp rates the interaction as moderate. Bendroflumethiazide and Captopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics and ACE inhibitors are often combined deliberately for additive blood pressure control. First-dose hypotension and renal function decline may occur, particularly in volume-depleted patients, and ACE inhibition counteracts thiazide-induced potassium loss.
How serious is the interaction between Bendroflumethiazide and Captopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with low doses, and monitor blood pressure, serum creatinine and electrolytes after initiation or dose changes. Consider reducing or holding the diuretic before starting captopril in volume-depleted patients.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
