Drug interactions
Bendroflumethiazide + Cefalexin
Severity: Minor
Bendroflumethiazide and Cefalexin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are organic anions secreted by renal tubular transporters, so cefalexin could modestly reduce thiazide clearance. Any rise in thiazide exposure is expected to be small and of little clinical consequence.
What this interaction means in plain words
Bendroflumethiazide and Cefalexin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible competition for renal tubular anion secretion (OAT pathways); clinical relevance is unproven.
What to do
No dose change is needed. Check blood pressure and electrolytes as usual during thiazide therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cefalexin
- Amikacin + Cefalexin Moderate
- Avelumab + Cefalexin Moderate
- Balstilimab + Cefalexin Moderate
- Bcg vaccine live + Cefalexin Moderate
- Cefalexin + Cholera vaccine Moderate
- Cefalexin + Gentamicin Moderate
Frequently asked questions
Can I take Bendroflumethiazide with Cefalexin?
MediHelp rates the interaction as minor. Bendroflumethiazide and Cefalexin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs are organic anions secreted by renal tubular transporters, so cefalexin could modestly reduce thiazide clearance. Any rise in thiazide exposure is expected to be small and of little clinical consequence.
How serious is the interaction between Bendroflumethiazide and Cefalexin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Check blood pressure and electrolytes as usual during thiazide therapy.
What other medicines interact with Cefalexin?
MediHelp also lists interactions of Cefalexin with, for example, Amikacin, Avelumab, Balstilimab. The full list is on the Cefalexin page.
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