Drug interactions
Bendroflumethiazide + Dexamethasone-tobramycin
Severity: Moderate
Bendroflumethiazide and Dexamethasone-tobramycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both corticosteroids and thiazide diuretics promote urinary potassium loss, so together they can cause hypokalemia. This is relevant with systemic steroids and less so with ophthalmic use.
What this interaction means in plain words
Bendroflumethiazide and Dexamethasone-tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive renal potassium wasting from thiazide action and glucocorticoid mineralocorticoid effects.
What to do
Monitor serum potassium during systemic steroid use and supplement potassium as needed. Take extra care in patients with heart disease or on digoxin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-tobramycin
Frequently asked questions
Can I take Bendroflumethiazide with Dexamethasone-tobramycin?
MediHelp rates the interaction as moderate. Bendroflumethiazide and Dexamethasone-tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both corticosteroids and thiazide diuretics promote urinary potassium loss, so together they can cause hypokalemia. This is relevant with systemic steroids and less so with ophthalmic use.
How serious is the interaction between Bendroflumethiazide and Dexamethasone-tobramycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium during systemic steroid use and supplement potassium as needed. Take extra care in patients with heart disease or on digoxin.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
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